Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 8/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31276647 | 0.79 | CNR1 (0.38) | CNR1TYK2IP6K1SCN9ASCN5A | |
| SCHEMBL20688931 | 0.79 | TYK2 (0.42) | CNR1TYK2IP6K1SCN9ASCN5A | |
| SCHEMBL365763 | 0.78 | SCN9A (0.43) | CNR1MAPK1IP6K1SCN9ASCN5A | |
| SCHEMBL20688112 | 0.76 | TYK2 (0.50) | CNR1TYK2IP6K1SCN9ASCN5A | |
| SCHEMBL11463519 | 0.74 | IP6K1 (0.46) | CNR1TYK2IP6K1SCN9ASCN5A | |
| SCHEMBL21238483 | 0.73 | TYK2 (0.46) | CNR1TYK2IP6K1SCN9ASCN5A | |
| SCHEMBL20697016 | 0.73 | TYK2 (0.44) | CNR1TYK2IP6K1SCN9ASCN5A | |
| SCHEMBL20697374 | 0.73 | CNR1 (0.37) | CNR1TYK2MAPK1IP6K1TSHR | |
| SCHEMBL11471405 | 0.73 | CNR1 (0.47) | CNR1TYK2IP6K1SCN9A | |
| SCHEMBL32689806 | 0.72 | PLAU (0.49) | CNR1TYK2IP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593432-A1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007861-A1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |