Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3767309 | 0.87 | KDM4E (0.46) | KDM4EALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL1018522 | 0.86 | MEN1 (0.42) | KDM4EALDH1A1SMN1; SMN2TSHRACKR3 | |
| SCHEMBL3647459 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL3693257 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL1023294 | 0.82 | MEN1 (0.40) | KDM4EALDH1A1SMN1; SMN2TSHRMEN1 | |
| SCHEMBL3762052 | 0.82 | ACKR3 (0.46) | KDM4EALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL1020212 | 0.77 | TP53 (0.46) | KDM4EALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL1018852 | 0.77 | MEN1 (0.42) | KDM4EALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL1019852 | 0.76 | ALDH1A1 (0.52) | KDM4EALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL1020125 | 0.76 | ALDH1A1 (0.49) | KDM4EALDH1A1HTTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190827-A1 | N-BENZYL, N' -ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | N.V. Organon (NL) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024550-A1 | N-BENZYL, N' -ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS | N.V. ORGANON (NL) | 2009-02-26 | — | — | WO | disclosed |