Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13285437 | 0.89 | OPRM1 (0.53) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3705210 | 0.89 | CYP2C19 (0.54) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3774236 | 0.88 | OPRM1 (0.52) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3691806 | 0.86 | OPRM1 (0.71) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3886739 | 0.86 | OPRM1 (0.52) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3693028 | 0.85 | OPRM1 (0.73) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3700686 | 0.84 | OPRM1 (0.71) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL6104862 | 0.84 | OPRM1 (0.48) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3695492 | 0.84 | OPRM1 (0.60) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL13285562 | 0.83 | CYP2D6 (0.49) | OPRM1OPRD1OPRK1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |