Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.31 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3703228 | 0.94 | HTR2C (0.45) | HTR2CSLC6A4HTR2ASCN9ASLC16A3 | |
| SCHEMBL3700534 | 0.94 | HTR2C (0.45) | HTR2CSLC6A4HTR2ASCN9ASLC16A3 | |
| SCHEMBL3697267 | 0.94 | HTR2C (0.48) | HTR2CSLC6A4HTR2ASCN9ASCN5A | |
| SCHEMBL3695135 | 0.91 | HTR2C (0.44) | HTR2CSLC6A4HTR2ARXRAGRIN1 | |
| SCHEMBL3696768 | 0.90 | HTR2C (0.45) | HTR2CSLC6A4HTR2ARXRAGRIN1 | |
| SCHEMBL3695013 | 0.89 | HTR2C (0.43) | HTR2CSLC6A4HTR2ACCNE2CCNE1 | |
| SCHEMBL3696458 | 0.89 | HTR2C (0.43) | HTR2CSLC6A4HTR2ACCNE2CCNE1 | |
| SCHEMBL3029602 | 0.88 | HTR2C (0.49) | HTR2CSLC6A4HTR2ASLC16A3SLC16A1 | |
| SCHEMBL4127365 | 0.88 | SCN9A (0.35) | HTR2CSLC6A4SCN9ARXRAGRIN1 | |
| SCHEMBL3701837 | 0.88 | HTR2C (0.43) | HTR2CSLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |