Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3689432 | 0.93 | OPRM1 (0.58) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL13285434 | 0.89 | OPRM1 (0.59) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3689784 | 0.89 | OPRM1 (0.52) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3698877 | 0.89 | OPRM1 (0.58) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3699256 | 0.88 | OPRM1 (0.57) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3695960 | 0.86 | OPRM1 (0.68) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3702154 | 0.85 | OPRM1 (0.54) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3698864 | 0.82 | OPRM1 (0.73) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3691955 | 0.81 | OPRM1 (0.54) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3695640 | 0.81 | OPRM1 (0.61) | OPRM1OPRK1OPRD1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |