Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.34 |
| ▸ | CDK2 | P24941 | 10/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 8/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27590173 | 1.00 | EPHX1 (0.39) | EPHX1NAAADPP4GBA1CCNE1 | |
| SCHEMBL27813829 | 0.90 | DPP4 (0.37) | DPP4CCNE1CDK2GSK3B | |
| SCHEMBL28310773 | 0.88 | NAAA (0.40) | EPHX1NAAADPP4CCNE1CDK2 | |
| SCHEMBL7815595 | 0.87 | EPHX1 (0.42) | EPHX1DPP4CCNE1CDK2GSK3B | |
| Methane SCHEMBL27968861 | 0.85 | EPHX1 (0.41) | EPHX1DPP4CCNE1CDK2GSK3B | |
| SCHEMBL14738614 | 0.85 | EPHX1 (0.38) | EPHX1NAAADPP4CCNE1CDK2 | |
| SCHEMBL14738613 | 0.85 | EPHX1 (0.38) | EPHX1NAAADPP4CCNE1CDK2 | |
| SCHEMBL5162091 | 0.85 | PLG (0.39) | EPHX1NAAADPP4CCNE1CDK2 | |
| SCHEMBL5162097 | 0.85 | PLG (0.39) | EPHX1NAAADPP4CCNE1CDK2 | |
| SCHEMBL27820555 | 0.84 | DPP4 (0.39) | EPHX1DPP4GBA1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |