Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022279 | 0.81 | MAPK13 (0.42) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL1840518 | 0.80 | NPC1 (0.45) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL26104359 | 0.80 | PTGES (0.43) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL30361871 | 0.80 | PTGES (0.43) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL1665479 | 0.80 | TNKS (0.51) | MAPK13RAF1MAPK9MAPK12MAPK11 | |
| SCHEMBL29459254 | 0.78 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBRPS6KA3 | |
| SCHEMBL9175737 | 0.78 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBRPS6KA3 | |
| SCHEMBL23624775 | 0.78 | MAPK13 (0.47) | PI4KAPI4K2BPI4K2API4KBMAPK13 | |
| SCHEMBL17224938 | 0.78 | TNKS (0.49) | MAPK13RAF1MAPK9MAPK12MAPK11 | |
| SCHEMBL26499870 | 0.77 | PI4KA (0.50) | PI4KAPI4K2BPI4K2API4KBMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088574-A1 | AZABENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-08-05 | — | — | WO | disclosed |