Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3693757 | 1.00 | ALDH1A1 (0.49) | ALDH1A1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL3645649 | 0.85 | ALDH1A1 (0.66) | ALDH1A1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL3645648 | 0.85 | ALDH1A1 (0.66) | ALDH1A1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL3645761 | 0.80 | MAOB (0.51) | ALDH1A1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL5040549 | 0.78 | MEN1 (0.55) | ALDH1A1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL5040554 | 0.78 | MEN1 (0.55) | ALDH1A1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL5033317 | 0.72 | IDO1 (0.48) | ALDH1A1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL5033321 | 0.72 | IDO1 (0.48) | ALDH1A1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL11715338 | 0.72 | ALDH1A1 (0.68) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL5042843 | 0.72 | CYP3A4 (0.51) | RAB9ANPC1CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2182950-A1 | USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS | Helperby Therapeutics Limited (GB) | 2010-05-12 | — | — | EP | disclosed |
| WO-2008142384-A1 | USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS | HELPERBY THERAPEUTICS LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |