Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 15/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3690748 | 0.90 | OPRM1 (0.56) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3695640 | 0.90 | OPRM1 (0.61) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3694413 | 0.90 | OPRM1 (0.56) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3695960 | 0.89 | OPRM1 (0.68) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3693982 | 0.87 | OPRM1 (0.53) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL13285434 | 0.84 | OPRM1 (0.59) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3698075 | 0.83 | OPRM1 (0.53) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3694801 | 0.83 | OPRM1 (0.55) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3698877 | 0.83 | OPRM1 (0.58) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL3693553 | 0.83 | OPRM1 (0.50) | OPRM1OPRD1OPRK1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |
| CN-1305852-C | Diaryl ethers as opioid receptor antagonists | LILLY CO ELI (US) | 2007-03-21 | — | — | CN | disclosed |
| CN-1681498-A | Diaryl ethers as opioid receptor antagonist | LILLY CO ELI (US) | 2005-10-12 | — | — | CN | disclosed |