Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 17/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 15/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694156 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3692306 | 0.94 | OPRM1 (1.00) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3690327 | 0.92 | OPRM1 (1.00) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL27569191 | 0.92 | OPRM1 (0.85) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3702304 | 0.91 | OPRM1 (0.83) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3700181 | 0.91 | OPRM1 (1.00) | OPRM1OPRD1OPRK1 | |
| SCHEMBL27550519 | 0.91 | OPRM1 (0.83) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL27569267 | 0.90 | OPRM1 (0.82) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL27572242 | 0.89 | OPRM1 (0.80) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3761851 | 0.89 | OPRM1 (1.00) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |
| CN-1305852-C | Diaryl ethers as opioid receptor antagonists | LILLY CO ELI (US) | 2007-03-21 | — | — | CN | disclosed |
| CN-1681498-A | Diaryl ethers as opioid receptor antagonist | LILLY CO ELI (US) | 2005-10-12 | — | — | CN | disclosed |