⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166437 | 1.00 | — | — | |
| SCHEMBL7198390 | 1.00 | — | — | |
| SCHEMBL25144056 | 0.95 | CA1 (0.41) | — | |
| SCHEMBL25144499 | 0.88 | CA1 (0.37) | — | |
| SCHEMBL25144280 | 0.88 | CA1 (0.37) | — | |
| SCHEMBL8914013 | 0.85 | ALDH1A1 (0.48) | — | |
| SCHEMBL12943060 | 0.85 | ALDH1A1 (0.48) | — | |
| SCHEMBL2705849 | 0.85 | ALDH1A1 (0.48) | — | |
| SCHEMBL2705851 | 0.85 | ALDH1A1 (0.48) | — | |
| SCHEMBL1296897 | 0.85 | ALDH1A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8092186-A | — | — | None | — | — | JP | disclosed |
| CN-119504397-A | Synthesis method of 2-fluorocyclopropane carboxylic acid | 上海裕兰生物科技有限公司 | 2025-02-25 | — | — | CN | disclosed |
| EP-3541804-B1 | CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2025-01-22 | — | — | EP | disclosed |
| CN-114380820-A | Hetero-fused ring derivative and application thereof in medicine | 海思科医药集团股份有限公司 | 2022-04-22 | — | — | CN | disclosed |
| US-11020395-B2 | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor | AMGEN INC. (US) | 2021-06-01 | — | — | US | disclosed |
| US-20190290648-A1 | CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2019-09-26 | — | — | US | disclosed |
| EP-1792889-B1 | Process for the preparation of carboxylic acid esters | SUMITOMO CHEMICAL CO (JP) | 2015-03-04 | — | — | EP | disclosed |
| EP-2794605-A1 | 2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| EP-1731499-B1 | PROCESS FOR PRODUCING 1,2-CIS-2-FLUOROCYCLOPROPANE-1-CARBOXYLIC ESTER COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2014-10-01 | — | — | EP | disclosed |
| EP-2748159-A1 | SERINE/THREONINE PAK1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-02 | — | — | EP | disclosed |
| US-20050113581-A1 | Process for the preparation of carboxylic acid esters | SUMITOMO CHEMICAL COMPANY, LIMITED | 2005-05-26 | — | — | US | disclosed |
| US-6596898-B2 | Making a 2-fluoro-2-chlorocyclopropanecarboxylic acid derivative stereoselectively in high yield by reacting a diazoacetic acid derivative with 1-fluoro-1-chloroethylene using metal catalyst having chiral ligands | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| US-20010051750-A1 | PROCESS FOR PREPARING HALOGENATED CYCLOPROPANE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-12-13 | — | — | US | disclosed |
| EP-0858992-B1 | PROCESS FOR PRODUCING HALOGENATED CYCLOPROPANE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-6130350-A | Process for producing 2-fluorine-1-cyclopropane carboxylic acid derivatives by reductive dehalogenation | BAYER AKTIENGESELLSCHAFT (DE) | 2000-10-10 | — | — | US | disclosed |
| EP-0712831-B1 | SELECTIVE DEHALOGENATION METHOD | DAIICHI SEIYAKU CO (JP) | 1999-11-03 | — | — | EP | disclosed |
| EP-0858992-A1 | PROCESS FOR PRODUCING HALOGENATED CYCLOPROPANE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5780669-A | Selective dehalogenation process | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-07-14 | — | — | US | disclosed |
| EP-0712831-A1 | SELECTIVE DEHALOGENATION METHOD | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1996-05-22 | — | — | EP | disclosed |
| JP-H0892186-A | PRODUCTION OF OPTICALLY ACTIVE CIS-2-FLUOROCYCLOPROPANECARBOHYDRAZIDE | SUMITOMO CHEM CO LTD | 1996-04-09 | — | — | JP | disclosed |