Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | VEGFA | P15692 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16509736 | 0.84 | BRD4 (0.56) | PKMPOLBEGLN1VEGFAMAPT | |
| SCHEMBL19513364 | 0.83 | MAPT (0.70) | PKMPOLBEGLN1VEGFAMAPT | |
| SCHEMBL19513455 | 0.81 | MAPT (0.53) | PKMPOLBEGLN1VEGFAMAPT | |
| SCHEMBL29348731 | 0.80 | HDAC3 (0.52) | PKMPOLBEGLN1VEGFAMAPT | |
| SCHEMBL12599486 | 0.78 | EGLN1 (0.71) | PKMPOLBEGLN1MAPTTP53 | |
| SCHEMBL19501367 | 0.78 | EGLN1 (0.53) | PKMPOLBEGLN1VEGFAMAPT | |
| SCHEMBL16579510 | 0.76 | ITGB1 (0.57) | PKMPOLBEGLN1VEGFAMAPT | |
| SCHEMBL27383780 | 0.75 | MAPT (0.68) | PKMPOLBEGLN1MAPTTP53 | |
| SCHEMBL14221240 | 0.74 | LMNA (0.57) | PKMPOLBEGLN1VEGFAMAPT | |
| SCHEMBL28105294 | 0.74 | POLB (0.54) | POLBKDM4EALDH1A1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |