Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29430412 | 0.97 | — | — | |
| SCHEMBL54892 | 0.97 | — | — | |
| Hydrogen Sulfide SCHEMBL2321786 | 0.95 | — | — | |
| Fluoride SCHEMBL6702411 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL3749785 | 0.95 | — | — | |
| Iodide SCHEMBL23406241 | 0.95 | — | — | |
| Benzene SCHEMBL11013308 | 0.95 | HRH1 (0.52) | HRH1HRH3ALDH1A1TDP1SMN1; SMN2 | |
| Bromide SCHEMBL4952663 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL11412754 | 0.95 | HRH1 (0.52) | HRH1HRH3ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL487341 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197922-A1 | OLEFIN POLYMERIZATION CATALYSTS, THEIR SYNTHESIS AND USE | ExxonMobil Chemical Patents Inc. (US) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009045625-A1 | OLEFIN POLYMERIZATION CATALYSTS, THEIR SYNTHESIS AND USE | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2009-04-09 | — | — | WO | disclosed |