Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950474 | 0.80 | KDM4E (0.53) | KDM4EPAX8LMNAALDH1A1KMT2A | |
| SCHEMBL25383409 | 0.77 | ALDH1A1 (0.45) | NPC1KDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL3705317 | 0.77 | MAPT (0.63) | NPC1KDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL29788525 | 0.77 | HTT (0.59) | KDM4ELMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL18970268 | 0.74 | ALDH1A1 (0.51) | KDM4ELMNAALDH1A1CHEK1CYP2C19 | |
| SCHEMBL2946935 | 0.74 | ALDH1A1 (0.46) | NPC1KDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL375580 | 0.74 | KDM4E (0.68) | NPC1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL29788583 | 0.74 | KDM4E (0.68) | NPC1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL24346247 | 0.73 | ALDH1A1 (0.50) | KDM4ELMNAALDH1A1CHEK1SIRT6 | |
| SCHEMBL1230074 | 0.73 | ALDH1A1 (0.77) | LMNAALDH1A1KMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VHL, TP53, ASAH2 | NPC1 118/4885KDM4E 3146/4885PAX8 2916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.