Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11417037 | 0.83 | TAAR1 (0.48) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3390149 | 0.83 | TAAR1 (0.59) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18419705 | 0.78 | TAAR1 (0.46) | TAAR1CYP2C19CYP3A4MAPK1TP53 | |
| SCHEMBL13721736 | 0.78 | CYP1A2 (0.52) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10601271 | 0.76 | TAAR1 (0.56) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL115909 | 0.76 | TAAR1 (0.56) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10417846 | 0.76 | TAAR1 (0.56) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14910579 | 0.76 | TAAR1 (0.56) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8623309 | 0.75 | CYP2C19 (0.44) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4667150 | 0.74 | ALDH1A1 (0.43) | TAAR1CYP2C19CYP3A4MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095337-A2 | PYRAZOLO[1,5-a]PYRIMIDINECARBOXAMIDE DERIVATIVES FOR TREATING COGNITIVE IMPAIRMENT | THE ROCKEFELLER UNIVERSITY (US) | 2015-06-25 | — | — | WO | disclosed |
| US-7786191-B2 | Process for melt-shaping a polymer composition | DSM IP ASSETS B.V. (NL) | 2010-08-31 | — | — | US | disclosed |
| EP-1276601-B1 | PROCESS AND INSTALLATION FOR THE PREPARATION OF A GRANULE MIXTURE, AND GRANULE MIXTURE | DSM IP ASSETS BV (NL) | 2004-08-18 | — | — | EP | disclosed |
| US-20030160358-A1 | Process for melt-shaping a polymer composition | DSM IP ASSETS B.V. (NL) | 2003-08-28 | — | — | US | disclosed |
| EP-1276601-A1 | PROCESS FOR MELT-SHAPING A POLYMER COMPOSITION | DSM N.V. (NL) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001081067-A1 | PROCESS FOR MELT-SHAPING A POLYMER COMPOSITION | DSM N.V. (NL) | 2001-11-01 | — | — | WO | disclosed |