Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 11/20 | 0.55 |
| ▸ | RAB9A | P51151 | 11/20 | 0.55 |
| ▸ | MEN1 | O00255 | 10/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.47 |
| ▸ | RELA | Q04206 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370788 | 0.91 | GRM4 (0.57) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL365863 | 0.89 | NPC1 (0.68) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL368073 | 0.80 | GRM4 (0.68) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL369427 | 0.80 | GRM4 (0.72) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL370159 | 0.78 | GRM4 (0.52) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL370597 | 0.78 | GRM4 (0.57) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL367354 | 0.75 | GRM4 (0.68) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL366756 | 0.74 | GRM4 (0.74) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL12482364 | 0.74 | GRM4 (0.53) | GRM4KCNH2NPC1RAB9AMEN1 | |
| SCHEMBL370659 | 0.74 | GRM4 (0.51) | GRM4KCNH2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |