Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 9/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.40 |
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370490 | 0.86 | GRM4 (0.67) | GRM4KCNH2GRM8RAB9ACYP1A2 | |
| SCHEMBL365856 | 0.84 | GRM4 (0.69) | GRM4KCNH2GRM8CYP1A2ALOX5 | |
| SCHEMBL368073 | 0.82 | GRM4 (0.68) | GRM4KCNH2MEN1KMT2ANPC1 | |
| SCHEMBL369856 | 0.78 | GRM4 (0.55) | GRM4KCNH2GRM8MEN1KMT2A | |
| SCHEMBL370650 | 0.78 | GRM4 (0.65) | GRM4KCNH2GRM8RAB9ACYP1A2 | |
| SCHEMBL369427 | 0.74 | GRM4 (0.72) | GRM4KCNH2GRM8MEN1KMT2A | |
| SCHEMBL365863 | 0.74 | NPC1 (0.68) | GRM4KCNH2MEN1KMT2ANPC1 | |
| SCHEMBL369134 | 0.73 | GRM4 (0.68) | GRM4KCNH2GRM8TRPV4ALOX5 | |
| SCHEMBL370373 | 0.72 | GRM4 (0.51) | GRM4KCNH2GRM8 | |
| SCHEMBL370275 | 0.72 | GRM4 (0.73) | GRM4KCNH2GRM8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |