Sugi Predict

Sugi Predict / Compounds / SCHEMBL369949

SCHEMBL369949

SCHEMBL369949

CCN(C)c1n[nH]cc1-c1csc(Nc2ncccn2)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 12/20 0.47
▸ KMT2A Q03164 12/20 0.47
▸ ATM Q13315 1/20 0.47
▸ TRPV4 Q9HBA0 1/20 0.46
▸ NPC1 O15118 11/20 0.46
▸ RAB9A P51151 11/20 0.46
▸ SMN1; SMN2 Q16637 11/20 0.46
▸ MAPT P10636 9/20 0.46
▸ ALDH1A1 P00352 6/20 0.46
▸ POLB P06746 5/20 0.46
▸ NFKB1 P19838 5/20 0.46
▸ NFKB2 Q00653 5/20 0.46
▸ RELA Q04206 5/20 0.46
▸ TYR P14679 2/20 0.46
▸ HTT P42858 3/20 0.43
▸ THRB P10828 2/20 0.43
▸ MCL1 Q07820 2/20 0.43
▸ TDP1 Q9NUW8 2/20 0.43
▸ APEX1 P27695 1/20 0.43
▸ CYP1A2 P05177 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL370908 0.87 MEN1 (0.44) MEN1KMT2AATMTRPV4NPC1
SCHEMBL369465 0.77 KMT2A (0.52) MEN1KMT2AATMTRPV4NPC1
SCHEMBL370647 0.71 MEN1 (0.52) MEN1KMT2AATMTRPV4NPC1
SCHEMBL370972 0.69 GRM4 (0.53) MEN1KMT2AATMTRPV4NPC1
SCHEMBL370539 0.69 GRM4 (0.58) MEN1KMT2ATRPV4NPC1RAB9A
SCHEMBL370434 0.68 MEN1 (0.42) MEN1KMT2AATMTRPV4NPC1
SCHEMBL369252 0.68 NPC1 (0.53) MEN1KMT2AATMTRPV4NPC1
SCHEMBL15166609 0.67 MEN1 (0.39) MEN1KMT2AATMTRPV4NPC1
SCHEMBL2538671 0.67 NPC1 (0.44) MEN1KMT2AATMTRPV4NPC1
SCHEMBL370036 0.67 RAB9A (0.52) MEN1KMT2AATMTRPV4NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9073907-B2 Thiazoles derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors ADDEX PHARMA S.A. (CH) 2015-07-07 — — US claimed
EP-2376486-B1 NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMACEUTICALS SA (CH) 2013-11-06 — — EP claimed
US-20110257179-A1 NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMA SA (CH) 2011-10-20 — — US claimed
EP-2595986-A2 NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Addex Pharma SA (CH) 2013-05-29 — — EP disclosed
WO-2012009009-A2 NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMA S.A. (CH) 2012-01-19 — — WO disclosed
US-20110257179-A1 NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMA SA (CH) 2011-10-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110257179-A1 NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS GRM4, GRM2, GRM1 MEN1 3967/4885KMT2A 2333/4885ATM 3282/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.