Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370832 | 0.89 | GRM4 (0.59) | GRM4KCNH2ALDH1A1GRM8ADORA2A | |
| SCHEMBL15166602 | 0.87 | GRM4 (0.59) | GRM4KCNH2ROCK2ALDH1A1CHEK1 | |
| SCHEMBL15166711 | 0.84 | GRM4 (0.67) | GRM4KCNH2ALDH1A1GRM8TRPV4 | |
| SCHEMBL15166592 | 0.83 | GRM4 (0.68) | GRM4KCNH2ALDH1A1GRM8ADORA2A | |
| SCHEMBL365867 | 0.74 | GRM4 (0.71) | GRM4KCNH2ALDH1A1GRM8TRPV4 | |
| SCHEMBL369663 | 0.74 | GRM4 (0.73) | GRM4KCNH2ALDH1A1GRM8TRPV4 | |
| SCHEMBL369428 | 0.73 | GRM4 (0.62) | GRM4KCNH2ROCK2CHEK1GRM8 | |
| SCHEMBL370314 | 0.70 | GRM4 (0.70) | GRM4KCNH2ALDH1A1GRM8FYN | |
| SCHEMBL369152 | 0.67 | GRM4 (1.00) | GRM4KCNH2ALDH1A1GRM8TRPV4 | |
| SCHEMBL370857 | 0.66 | GRM4 (0.66) | GRM4KCNH2ROCK2CHEK1GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |