Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 8/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15166711 | 0.94 | GRM4 (0.67) | GRM4KCNH2GRM8FYNKDR | |
| SCHEMBL15166592 | 0.93 | GRM4 (0.68) | GRM4KCNH2GRM8FYNADORA2A | |
| SCHEMBL369958 | 0.89 | GRM4 (0.48) | GRM4KCNH2GRM8FYNADORA2A | |
| SCHEMBL365867 | 0.83 | GRM4 (0.71) | GRM4KCNH2GRM8FYNKDR | |
| SCHEMBL369663 | 0.83 | GRM4 (0.73) | GRM4KCNH2GRM8FYNKDR | |
| SCHEMBL370314 | 0.79 | GRM4 (0.70) | GRM4KCNH2GRM8FYNKDR | |
| SCHEMBL369152 | 0.75 | GRM4 (1.00) | GRM4KCNH2GRM8FYNKDR | |
| SCHEMBL2532786 | 0.74 | GRM4 (0.76) | GRM4KCNH2GRM8FYNKDR | |
| SCHEMBL367234 | 0.73 | GRM4 (0.74) | GRM4KCNH2GRM8FYNKDR | |
| SCHEMBL366756 | 0.73 | GRM4 (0.74) | GRM4KCNH2GRM8FYNKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |