Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.68 |
| ▸ | CASP4 | P49662 | 1/20 | 0.67 |
| ▸ | CASP5 | P51878 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | CASP9 | P55211 | 1/20 | 0.67 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.67 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.67 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 6/20 | 0.43 |
| ▸ | STAT5A | P42229 | 2/20 | 0.43 |
| ▸ | STAT5B | P51692 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 6/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20298320 | 1.00 | CASP1 (0.68) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL478382 | 1.00 | CASP1 (0.68) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL3058685 | 1.00 | CASP1 (0.68) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL12266527 | 0.92 | CASP1 (0.68) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL12266522 | 0.92 | CASP1 (0.68) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL13951168 | 0.92 | CASP1 (0.68) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL30628927 | 0.90 | CASP1 (0.66) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL478250 | 0.89 | CASP1 (0.67) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL12023624 | 0.89 | CASP1 (0.67) | CASP1CASP4CASP5CASP7CASP9 | |
| SCHEMBL21539807 | 0.88 | CASP1 (0.63) | CASP1CASP4CASP5CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018200958-A1 | COMBINED ADMINISTRATION OF CYSTEINE-ASPARTIC PROTEASE INHIBITORS WITH P2Y12 RECEPTOR ANTAGONISTS PROTECTS THE HEART AGAINST MYOCARDIAL INFARCTION | UNIVERSITY OF SOUTH ALABAMA (US) | 2018-11-01 | — | — | WO | claimed |
| WO-2015003246-A1 | COMBINATION OF A STATIN WITH AN INFLAMMASOME INHIBITOR | MCMASTER UNIVERSITY (CA) | 2015-01-15 | — | — | WO | claimed |
| WO-2023215559-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| EP-4225301-A1 | TREATMENTS OF CORONAVIRUS INFECTIONS, CYTOKINE RELEASE SYNDROME, CYTOKINE STORM SYNDROME, OR DISEASES ASSOCIATED WITH EXCESSIVE ACTIVATION OF INFLAMMASOMES BY THE USE OF INHIBITORS OF INFLAMMATORY CASPASES | Institut National de la Santé et de la Recherche Médicale (FR) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022074134-A1 | TREATMENTS OF CORONAVIRUS INFECTIONS, CYTOKINE RELEASE SYNDROME, CYTOKINE STORM SYNDROME, OR DISEASES ASSOCIATED WITH EXCESSIVE ACTIVATION OF INFLAMMASOMES BY THE USE OF INHIBITORS OF INFLAMMATORY CASPASES | JACOTOT ETIENNE (FR) | 2022-04-14 | — | — | WO | disclosed |
| EP-3914717-A1 | CLOSE-ENDED DNA (CEDNA) AND USE IN METHODS OF REDUCING GENE OR NUCLEIC ACID THERAPY RELATED IMMUNE RESPONSE | Generation Bio Co. (US) | 2021-12-01 | — | — | EP | disclosed |
| CN-113412331-A | Closed end DNA (ceDNA) and its use in methods of reducing immune responses associated with gene or nucleic acid therapy | 世代生物公司 | 2021-09-17 | — | — | CN | disclosed |
| WO-2020154645-A1 | CLOSE-ENDED DNA (CEDNA) AND USE IN METHODS OF REDUCING GENE OR NUCLEIC ACID THERAPY RELATED IMMUNE RESPONSE | GENERATION BIO CO. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2018200958-A1 | COMBINED ADMINISTRATION OF CYSTEINE-ASPARTIC PROTEASE INHIBITORS WITH P2Y12 RECEPTOR ANTAGONISTS PROTECTS THE HEART AGAINST MYOCARDIAL INFARCTION | UNIVERSITY OF SOUTH ALABAMA (US) | 2018-11-01 | — | — | WO | disclosed |
| WO-2015003246-A1 | COMBINATION OF A STATIN WITH AN INFLAMMASOME INHIBITOR | MCMASTER UNIVERSITY (CA) | 2015-01-15 | — | — | WO | disclosed |
| WO-2010071866-A2 | COMBINATION THERAPY FOR ARTHRITIS WITH TRANILAST | NUON THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | WO | disclosed |