Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 9/20 | 0.56 |
| ▸ | RAMP1 | O60894 | 4/20 | 0.52 |
| ▸ | RAMP3 | O60896 | 1/20 | 0.49 |
| ▸ | CALCR | P30988 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12921051 | 0.88 | CALCRL (0.53) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL6343402 | 0.86 | CALCRL (0.50) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL979114 | 0.85 | CALCRL (0.48) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL978956 | 0.82 | CALCRL (0.48) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL979401 | 0.81 | CALCRL (0.47) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL12921090 | 0.81 | CALCRL (0.47) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL12921052 | 0.80 | CALCRL (0.38) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL978963 | 0.79 | CALCRL (0.44) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL15354517 | 0.79 | CALCRL (0.42) | CALCRLRAMP1RAMP3CALCRKMT2A | |
| SCHEMBL12901354 | 0.78 | HCAR3 (0.38) | CALCRLRAMP1RAMP3CALCRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765759-B2 | Monocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2271346-B1 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-01 | — | — | EP | disclosed |
| US-20120121508-A1 | RADIOLABELED CGRP ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120121508-A1 | RADIOLABELED CGRP ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120121508-A1 | RADIOLABELED CGRP ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120121508-A1 | RADIOLABELED CGRP ANTAGONISTS | CALCRL, CALCR, GRPR | CALCRL 1/4885RAMP1 54/4885RAMP3 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.