Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933095 | 0.88 | BACE1 (0.35) | ABL1BACE1RENCTSDBACE2 | |
| SCHEMBL932343 | 0.85 | BACE1 (0.37) | ABL1BACE1BACE2STING1 | |
| SCHEMBL932453 | 0.82 | BACE1 (0.36) | BACE1RENCTSDBACE2 | |
| SCHEMBL932068 | 0.82 | BACE1 (0.36) | BACE1RENCTSDBACE2 | |
| Hydrochloric Acid SCHEMBL934082 | 0.81 | BACE1 (0.36) | BACE1RENCTSDBACE2 | |
| SCHEMBL933031 | 0.80 | BACE1 (0.36) | BACE1CTSDBACE2 | |
| SCHEMBL12694657 | 0.79 | BACE1 (0.41) | ABL1BACE1RENCTSDBACE2 | |
| SCHEMBL4313717 | 0.71 | BACE1 (0.36) | ABL1BACE1RENCTSDBACE2 | |
| SCHEMBL3696178 | 0.71 | BACE1 (0.58) | BACE1CTSDBACE2 | |
| SCHEMBL933126 | 0.71 | KCNH2 (0.35) | ABL1BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-A1 | BACE INHIBITORS | Eli Lilly and Company (US) | 2012-05-16 | — | — | EP | disclosed |