Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 6/20 | 0.53 |
| ▸ | STK17B | O94768 | 4/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1916627 | 0.87 | CHEK1 (0.61) | STK17ASTK17BCHEK1 | |
| SCHEMBL3449758 | 0.81 | STK17A (0.56) | STK17ASTK17BMAPTCHEK1MAP3K8 | |
| SCHEMBL1917046 | 0.81 | CHEK1 (0.61) | STK17ASTK17BCHEK1MAP3K8EGFR | |
| SCHEMBL1916143 | 0.78 | STK17A (0.56) | STK17ASTK17BCHEK1 | |
| SCHEMBL13310836 | 0.78 | STK17A (0.52) | STK17ASTK17BMAPTMAP3K8EGFR | |
| SCHEMBL1919046 | 0.78 | STK17A (0.52) | STK17ASTK17BMAPTGSK3AGSK3B | |
| SCHEMBL3284584 | 0.77 | STK17A (0.55) | STK17ASTK17BCHEK1 | |
| SCHEMBL1916744 | 0.77 | BRD4 (0.55) | STK17ASTK17BCHEK1 | |
| SCHEMBL1916754 | 0.76 | STK17A (0.63) | STK17ASTK17BCHEK1 | |
| SCHEMBL3447547 | 0.76 | EGFR (0.58) | STK17ASTK17BMAP3K8EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090571-B1 | Pyrimidine derivates, medicaments comprising them, their use and process of their preparation | BOEHRINGER INGELHEIM PHARMA (DE) | 2012-05-16 | — | — | EP | disclosed |