Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.56 |
| ▸ | STK17B | O94768 | 3/20 | 0.56 |
| ▸ | MAP3K8 | P41279 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.49 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3447547 | 0.94 | EGFR (0.58) | STK17ASTK17BMAP3K8EGFRMARK3 | |
| SCHEMBL3448511 | 0.88 | STK17A (0.55) | STK17ASTK17BMAP3K8TBK1AXL | |
| SCHEMBL13310836 | 0.85 | STK17A (0.52) | STK17ASTK17BMAP3K8EGFRAXL | |
| SCHEMBL3449683 | 0.84 | AXL (0.62) | STK17ASTK17BMAP3K8EGFRTBK1 | |
| SCHEMBL3449465 | 0.82 | STK17A (0.55) | STK17ASTK17BEGFRTBK1AXL | |
| SCHEMBL3449182 | 0.82 | STK17A (0.52) | STK17ASTK17BMAP3K8EGFRTBK1 | |
| SCHEMBL3700191 | 0.81 | STK17A (0.53) | STK17ASTK17BMAP3K8EGFRMAPT | |
| SCHEMBL3451485 | 0.81 | STK17A (0.47) | STK17ASTK17BMAP3K8EGFRAXL | |
| SCHEMBL1916627 | 0.80 | CHEK1 (0.61) | STK17ASTK17BRPS6KA4KITFLT3 | |
| SCHEMBL13310824 | 0.80 | EGFR (0.56) | STK17ASTK17BMAP3K8EGFRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | STK17A 1984/4885STK17B 2457/4885MAP3K8 3307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.