Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | POLM | Q9NP87 | 2/20 | 0.48 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.48 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.48 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | FABP7 | O15540 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27546336 | 0.94 | KMT2A (0.57) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL30942571 | 0.94 | KMT2A (0.57) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL8207207 | 0.90 | MEN1 (0.51) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL16756230 | 0.88 | KDM4E (0.75) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL15558838 | 0.86 | KMT2A (0.56) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL15547583 | 0.84 | KDM4E (0.71) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL15547682 | 0.84 | KDM4E (0.71) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL15548749 | 0.83 | KDM4E (0.69) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL16239240 | 0.83 | KDM4E (0.69) | KMT2AKDM4EMEN1RECQLPOLM | |
| SCHEMBL15548684 | 0.83 | KDM4E (0.69) | KMT2AKDM4EMEN1RECQLPOLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668599-A1 | SULFONYLUREAS AND SULFONYLTHIOUREAS AS NLRP3 INHIBITORS | Inflazome Limited (IE) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034690-A1 | SULFONYLUREAS AND SULFONYLTHIOUREAS AS NLRP3 INHIBITORS | INFLAZOME LIMITED (IE) | 2019-02-21 | — | — | WO | disclosed |
| EP-2593427-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007883-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |