Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 16/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696130 | 0.88 | OPRM1 (0.53) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3701688 | 0.87 | OPRM1 (0.53) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3694866 | 0.84 | OPRM1 (0.50) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3697068 | 0.80 | OPRM1 (0.57) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3692327 | 0.79 | OPRM1 (0.64) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3689288 | 0.79 | OPRM1 (0.56) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3695960 | 0.79 | OPRM1 (0.68) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3698628 | 0.78 | OPRM1 (0.49) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3702499 | 0.78 | OPRM1 (0.55) | OPRM1OPRK1OPRD1GRIN2DGRIN3B | |
| SCHEMBL3696006 | 0.78 | OPRM1 (0.57) | OPRM1OPRK1OPRD1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |