Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.44 |
| ▸ | NPC1 | O15118 | 11/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 9/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | TYR | P14679 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369557 | 0.95 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL370858 | 0.91 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL369774 | 0.85 | GRM4 (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL370530 | 0.80 | GRM4 (0.47) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL370972 | 0.71 | GRM4 (0.53) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL369500 | 0.70 | GRM4 (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL370142 | 0.68 | GRM4 (0.50) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL370790 | 0.65 | MEN1 (0.51) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL371225 | 0.61 | GRM4 (0.72) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12295950 | 0.61 | MEN1 (1.00) | RAB9ANPC1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |