Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.53 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3692086 | 0.88 | OPRM1 (0.68) | OPRM1OPRD1OPRK1P2RY1ABCB1 | |
| SCHEMBL3690628 | 0.86 | OPRM1 (0.58) | OPRM1OPRD1OPRK1P2RY1ABCB1 | |
| SCHEMBL3702090 | 0.85 | OPRM1 (0.56) | OPRM1OPRD1OPRK1P2RY1ABCB1 | |
| SCHEMBL3699158 | 0.84 | OPRM1 (0.52) | OPRM1OPRD1OPRK1P2RY1ABCB1 | |
| SCHEMBL3694172 | 0.84 | OPRM1 (0.51) | OPRM1OPRD1OPRK1ABCB1MEN1 | |
| SCHEMBL3698501 | 0.83 | OPRM1 (0.57) | OPRM1OPRD1OPRK1P2RY1ABCB1 | |
| SCHEMBL3697430 | 0.83 | OPRM1 (0.50) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3690809 | 0.83 | OPRM1 (0.69) | OPRM1OPRD1OPRK1P2RY1ABCB1 | |
| SCHEMBL3694536 | 0.81 | OPRM1 (0.62) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3693672 | 0.81 | OPRM1 (0.70) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |