Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.44 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.44 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.44 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.44 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.44 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.44 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359504 | 0.94 | GPR119 (0.52) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL358194 | 0.90 | PDE4B (0.53) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL19297092 | 0.82 | GPR119 (0.52) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL23249899 | 0.82 | GPR119 (0.48) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14453644 | 0.81 | GPR119 (0.52) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL28289254 | 0.80 | KDM4E (0.53) | LMNAMAPK1KDM4EEPHX2MAPT | |
| SCHEMBL70414 | 0.80 | KDM1A (0.53) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL16759524 | 0.79 | PDE4B (0.55) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL1545806 | 0.79 | GPR119 (0.46) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL13648181 | 0.79 | GPR119 (0.46) | GPR119PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593457-A1 | PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |