Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 4/20 | 0.61 |
| ▸ | TACR2 | P21452 | 4/20 | 0.53 |
| ▸ | TACR1 | P25103 | 3/20 | 0.53 |
| ▸ | UBE2M | P61081 | 9/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297448 | 0.94 | TACR3 (0.68) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL295922 | 0.91 | TACR3 (0.58) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL295534 | 0.88 | TACR3 (0.58) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL297464 | 0.84 | TACR2 (0.58) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL295480 | 0.84 | TACR2 (0.71) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL8042308 | 0.80 | TACR2 (0.51) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL296656 | 0.80 | TACR3 (0.77) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL297453 | 0.80 | TACR3 (0.77) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL8052979 | 0.80 | TACR3 (0.55) | TACR3TACR2TACR1UBE2MDCUN1D1 | |
| SCHEMBL297889 | 0.79 | TACR3 (0.50) | TACR3TACR2TACR1KCNH2CACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200982-B1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-03-14 | — | — | EP | disclosed |