Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | CTSD | P07339 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.55 |
| ▸ | WNT3A | P56704 | 3/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | TDO2 | P48775 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28199327 | 0.86 | NPC1 (0.62) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL21128714 | 0.86 | NPC1 (0.83) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL29987209 | 0.86 | NPC1 (0.83) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL15979734 | 0.86 | CTNNB1 (0.71) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL878658 | 0.84 | NPC1 (0.64) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL1448202 | 0.84 | NPC1 (0.64) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL29738645 | 0.84 | NPC1 (0.64) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL6488893 | 0.82 | NPC1 (0.62) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL598461 | 0.82 | L3MBTL1 (0.64) | NPC1CTSDALDH1A1KMT2AHTT | |
| SCHEMBL18907831 | 0.82 | NPC1 (0.62) | NPC1CTSDALDH1A1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0123441-B1 | VINCALEUKOBLASTINE DERIVATIVES | LILLY INDUSTRIES LIMITED (GB) | 1990-10-03 | — | — | EP | claimed |
| US-4675400-A | FORM CONJUGATES WITH IMMUNOGLOBULINS; ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1987-06-23 | — | — | US | claimed |
| US-4596676-A | Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids | LILLY INDUSTRIES LIMITED (GB) | 1986-06-24 | — | — | US | claimed |
| EP-0123441-A1 | Vincaleukoblastine derivatives | LILLY INDUSTRIES LIMITED (GB) | 1984-10-31 | — | — | EP | claimed |
| EP-2396017-A1 | APOLIPOPROTEIN A-I MIMICS | Cerenis Therapeutics SA (FR) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010093918-A1 | APOLIPOPROTEIN A-I MIMICS | CERENIS THERAPEUTICS SA (FR) | 2010-08-19 | — | — | WO | disclosed |
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| US-5840895-A | INTERMEDIATES FOR ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1998-11-24 | — | — | US | disclosed |
| US-5686442-A | ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |
| EP-0123441-B1 | VINCALEUKOBLASTINE DERIVATIVES | LILLY INDUSTRIES LIMITED (GB) | 1990-10-03 | — | — | EP | disclosed |
| US-4675400-A | FORM CONJUGATES WITH IMMUNOGLOBULINS; ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| US-4596676-A | Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids | LILLY INDUSTRIES LIMITED (GB) | 1986-06-24 | — | — | US | disclosed |
| EP-0123441-A1 | Vincaleukoblastine derivatives | LILLY INDUSTRIES LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |