Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 7/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 7/20 | 0.54 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.44 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712462 | 0.84 | KCNQ3 (0.72) | KCNQ3KCNQ2CACNA1HCACNA1GCACNA1I | |
| SCHEMBL3709636 | 0.81 | KCNQ3 (0.53) | KCNQ3KCNQ2CACNA1HCACNA1GCACNA1I | |
| SCHEMBL3700940 | 0.72 | SCN5A (0.47) | KCNQ3KCNQ2PTGS2KDM4EGPR139 | |
| SCHEMBL6126180 | 0.72 | KCNQ3 (0.64) | KCNQ3KCNQ2CACNA1HCACNA1GCACNA1I | |
| SCHEMBL1321371 | 0.72 | CACNA1H (0.48) | CACNA1HCACNA1GCACNA1IMAPK14KDM4E | |
| SCHEMBL3710258 | 0.72 | KCNQ3 (0.70) | KCNQ3KCNQ2CACNA1HCACNA1GCACNA1I | |
| SCHEMBL1321122 | 0.72 | NLRP3 (0.43) | CACNA1HCACNA1GCACNA1IWNT3AMAPK14 | |
| SCHEMBL3695035 | 0.71 | KCNQ3 (0.55) | KCNQ3KCNQ2MAPK14PTGS2KDM4E | |
| SCHEMBL3703662 | 0.70 | KCNQ3 (1.00) | KCNQ3KCNQ2NPC1RAB9AGPR139 | |
| SCHEMBL3701916 | 0.70 | MAPK14 (0.52) | KCNQ3KCNQ2WNT3AMAPK14PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609669-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | claimed |
| US-20120122888-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | claimed |
| US-8609669-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| WO-2012067822-A1 | PYRAZOLO [1, 5 -A] PYRIMIDIN POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122888-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122888-A1 | Potassium Channel Modulators | KCNQ1, KCNQ2, KCNJ2 | KCNQ3 4/4885KCNQ2 2/4885CACNA1H 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.