Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.56 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CASP3 | P42574 | 3/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370358 | 0.83 | GRM4 (0.56) | GRM4GRM8MEN1RAB9AKMT2A | |
| SCHEMBL370727 | 0.82 | GRM4 (0.73) | GRM4GRM8KDRMEN1NPC1 | |
| SCHEMBL369427 | 0.80 | GRM4 (0.72) | GRM4GRM8KDRMEN1NPC1 | |
| SCHEMBL369761 | 0.79 | GRM4 (0.70) | GRM4GRM8KDRMEN1NPC1 | |
| SCHEMBL369009 | 0.75 | GRM4 (0.67) | GRM4GRM8KDRMEN1NPC1 | |
| SCHEMBL15166648 | 0.74 | GRM4 (0.63) | GRM4GRM8MEN1RAB9AKMT2A | |
| SCHEMBL370597 | 0.74 | GRM4 (0.57) | GRM4GRM8KDRMEN1NPC1 | |
| SCHEMBL369775 | 0.74 | GRM4 (0.69) | GRM4GRM8KDRMEN1RAB9A | |
| SCHEMBL369152 | 0.73 | GRM4 (1.00) | GRM4GRM8KDRMEN1NPC1 | |
| SCHEMBL369922 | 0.73 | GRM4 (0.67) | GRM4GRM8KDRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | claimed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | claimed |