Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.47 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.47 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 7/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.34 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FABP1 | P07148 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338262 | 0.96 | LPAR1 (0.50) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3711134 | 0.94 | LPAR1 (0.42) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3700609 | 0.93 | LPAR1 (0.46) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3707582 | 0.93 | LPAR1 (0.39) | LPAR1LPAR2LPAR3IP6K1IP6K3 | |
| SCHEMBL3709238 | 0.92 | LPAR1 (0.41) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3702563 | 0.91 | NR1H4 (0.46) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3714465 | 0.90 | LPAR1 (0.45) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3712765 | 0.90 | LPAR1 (0.43) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL3702333 | 0.90 | LPAR1 (0.44) | LPAR1LPAR2LPAR3PPARDNR1H4 | |
| SCHEMBL2335596 | 0.90 | DGAT1 (0.44) | LPAR1LPAR2LPAR3PPARDNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |