Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 1.00 |
| ▸ | HPGD | P15428 | 9/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.73 |
| ▸ | TSHR | P16473 | 5/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203906 | 0.91 | HPGD (0.83) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL4200861 | 0.90 | HPGD (0.82) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL4205005 | 0.89 | ALDH1A1 (0.80) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL4200844 | 0.85 | ALDH1A1 (0.74) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL4204293 | 0.85 | KDM4E (1.00) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL4211070 | 0.85 | HPGD (1.00) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL4208747 | 0.84 | ALDH1A1 (0.73) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL4216054 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL4216052 | 0.82 | ALDH1A1 (0.76) | ALDH1A1HPGDHSD17B10HTTKDM4E | |
| SCHEMBL31351815 | 0.82 | HPGD (0.71) | ALDH1A1HPGDHSD17B10HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | disclosed |