Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sibutramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 15/20 | 0.79 |
| ▸ | SLC6A4 known ✓ | P31645 | 14/20 | 0.79 |
| ▸ | SLC6A2 known ✓ | P23975 | 7/20 | 0.79 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.79 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.79 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.79 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.79 |
| ▸ | HTR2A | P28223 | 1/20 | 0.79 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.79 |
| ▸ | HTR2B | P41595 | 1/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sibutramine SCHEMBL3715426 | 1.00 | SLC6A3 (0.79) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL3707037 | 1.00 | SLC6A3 (0.79) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL4804258 | 0.91 | SLC6A3 (0.85) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL4804264 | 0.89 | SLC6A3 (0.81) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL27434458 | 0.89 | SLC6A3 (0.85) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL2672138 | 0.89 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL16312 | 0.89 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL2955 | 0.89 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL3707643 | 0.89 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A | |
| Sibutramine SCHEMBL7189499 | 0.87 | CYP3A4 (1.00) | SLC6A3SLC6A4SLC6A2CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010082216-A2 | NOVEL SALTS OF SIBUTRAMINE AND THEIR CRYSTAL FORMS | MATRIX LABORATORIES LTD (IN) | 2010-07-22 | — | — | WO | disclosed |