Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.56 |
| ▸ | CFD | P00746 | 2/20 | 0.47 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 4/20 | 0.41 |
| ▸ | F10 | P00742 | 4/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706015 | 1.00 | SLC7A5 (0.56) | SLC7A5CFDTPSB2CYP4F2CYP4A11 | |
| SCHEMBL8186958 | 0.79 | SLC7A5 (0.56) | SLC7A5CYP4F2CYP4A11ALDH1A1GAA | |
| SCHEMBL21839394 | 0.78 | SLC7A5 (0.52) | SLC7A5CYP4F2CYP4A11ALDH1A1GAA | |
| SCHEMBL732469 | 0.78 | SLC7A5 (0.76) | SLC7A5ALDH1A1GAAGFERHSP90AB1 | |
| SCHEMBL4613338 | 0.78 | SLC7A5 (0.76) | SLC7A5ALDH1A1GAAGFERHSP90AB1 | |
| SCHEMBL693509 | 0.78 | SLC7A5 (0.76) | SLC7A5ALDH1A1GAAGFERHSP90AB1 | |
| Hydrochloric Acid SCHEMBL4863108 | 0.77 | SLC7A5 (0.74) | SLC7A5ALDH1A1GAAGFERHSP90AB1 | |
| SCHEMBL1990343 | 0.77 | SLC7A5 (0.54) | SLC7A5CYP4F2CYP4A11ALDH1A1GAA | |
| SCHEMBL27649234 | 0.77 | SLC7A5 (0.54) | SLC7A5CYP4F2CYP4A11ALDH1A1GAA | |
| SCHEMBL12400239 | 0.77 | SLC7A5 (0.68) | SLC7A5CYP4F2CYP4A11ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432768-B1 | NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES | SUMITOMO DAINIPPON PHARMA CO LTD (JP) | 2017-07-05 | — | — | EP | disclosed |
| US-9533978-B2 | Pyrimidine derivatives and their use in the treatment of cancer and further diseases | SUMITOMO DAINIPPON PHARMA CO., LTD (JP) | 2017-01-03 | — | — | US | disclosed |
| US-20150080396-A1 | Novel Pyrimidine Derivatives and Their Use in the Treatment of Cancer and Further Diseases | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2015-03-19 | — | — | US | disclosed |
| CN-102482233-A | Novel pyrimidine derivatives and their use in the treatment of cancer and other diseases | ASTRAZENECA AB SE | 2012-05-30 | — | — | CN | disclosed |
| US-20120122867-A1 | NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES | ASTRAZENECA UK LIMITED (GB) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122867-A1 | NOVEL PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND FURTHER DISEASES | TYMS, TYMP, DPYD | SLC7A5 1369/4885CFD 2744/4885TPSB2 2199/4885 |
| US-20150080396-A1 | Novel Pyrimidine Derivatives and Their Use in the Treatment of Cancer and Further Diseases | TYMS, TYMP, DPYD | SLC7A5 1369/4885CFD 2744/4885TPSB2 2199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.