Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 19/20 | 0.56 |
| ▸ | RAMP1 | O60894 | 11/20 | 0.56 |
| ▸ | RAMP3 | O60896 | 1/20 | 0.54 |
| ▸ | CALCR | P30988 | 1/20 | 0.54 |
| ▸ | ADM2 | Q7Z4H4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836788 | 0.86 | CALCRL (0.55) | CALCRLRAMP1RAMP3CALCRADM2 | |
| SCHEMBL17881437 | 0.86 | CALCRL (0.51) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL846226 | 0.86 | CALCRL (0.51) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL846512 | 0.85 | CALCRL (0.51) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL846704 | 0.85 | CALCRL (0.55) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL846279 | 0.84 | CALCRL (0.54) | CALCRLRAMP1RAMP3CALCRADM2 | |
| SCHEMBL846254 | 0.84 | CALCRL (0.56) | CALCRLRAMP1RAMP3CALCRADM2 | |
| SCHEMBL29518081 | 0.84 | CALCRL (0.61) | CALCRLRAMP1 | |
| SCHEMBL29997203 | 0.84 | CALCRL (0.61) | CALCRLRAMP1 | |
| SCHEMBL29559656 | 0.84 | CALCRL (0.61) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120121508-A1 | RADIOLABELED CGRP ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120121508-A1 | RADIOLABELED CGRP ANTAGONISTS | CALCRL, CALCR, GRPR | CALCRL 1/4885RAMP1 54/4885RAMP3 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.