Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.51 |
| ▸ | RAMP1 | O60894 | 15/20 | 0.51 |
| ▸ | RAMP3 | O60896 | 1/20 | 0.51 |
| ▸ | CALCR | P30988 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17881437 | 1.00 | CALCRL (0.51) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL260489 | 0.86 | ADM2 (0.55) | CALCRL | |
| SCHEMBL17881601 | 0.86 | ADM2 (0.55) | CALCRL | |
| SCHEMBL1818060 | 0.86 | ADM2 (0.55) | CALCRL | |
| SCHEMBL3706135 | 0.86 | CALCRL (0.56) | CALCRLRAMP1RAMP3CALCR | |
| SCHEMBL22110811 | 0.85 | CALCRL (0.51) | CALCRLRAMP1 | |
| SCHEMBL978566 | 0.82 | CALCRL (0.50) | CALCRLRAMP1 | |
| SCHEMBL977185 | 0.82 | CALCRL (0.50) | CALCRLRAMP1 | |
| SCHEMBL838209 | 0.82 | CALCRL (0.50) | CALCRLRAMP1 | |
| SCHEMBL31126001 | 0.82 | CALCRL (0.50) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143266-B2 | Aryl heterocyclic CGRP receptor antagonists | Merck, Sharp & Dohme Corp (US) | 2012-03-27 | — | — | US | disclosed |