SCHEMBL3706296

SCHEMBL3706296

CN1C(=O)/C(=C\c2ccc(N(C)C)cc2)N=C1c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 6/20 0.61
KMT2A Q03164 5/20 0.59
L3MBTL1 Q9Y468 2/20 0.59
MAPT P10636 2/20 0.49
APP P05067 1/20 0.49
SNCA P37840 1/20 0.49
NOX4 Q9NPH5 2/20 0.48
NOX1 Q9Y5S8 1/20 0.48
CYBB P04839 1/20 0.48
CNR2 P34972 1/20 0.46
MEN1 O00255 4/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
GPR35 Q9HC97 1/20 0.46
KDM4E B2RXH2 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
GAA P10253 1/20 0.44
MCL1 Q07820 1/20 0.44
S1PR1 P21453 1/20 0.44
S1PR3 Q99500 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12960511 1.00 KDR (0.61) KDRKMT2AL3MBTL1MAPTAPP
SCHEMBL3706297 1.00 KDR (0.61) KDRKMT2AL3MBTL1MAPTAPP
SCHEMBL21217202 0.87 KMT2A (0.64) KDRKMT2AL3MBTL1MAPTMEN1
SCHEMBL21036819 0.85 CYBB (0.54) KDRKMT2AL3MBTL1MAPTNOX4
SCHEMBL21217195 0.84 KMT2A (0.61) KDRKMT2AL3MBTL1MAPTMEN1
SCHEMBL3787867 0.79 MEN1 (0.51) KDRKMT2AMAPTAPPSNCA
SCHEMBL12960495 0.79 MEN1 (0.51) KDRKMT2AMAPTAPPSNCA
SCHEMBL12804943 0.79 MEN1 (0.51) KDRKMT2AMAPTAPPSNCA
SCHEMBL21217184 0.78 KMT2A (0.55) KMT2AL3MBTL1MAPTKDM4ENPSR1
SCHEMBL21342237 0.77 CNR2 (0.49) KDRKMT2AMAPTAPPSNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2398775-B1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE UNIV CORNELL (US) 2019-04-24 EP claimed
US-20120252699-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE CORNELL UNIVERSITY (US) 2012-10-04 US claimed
EP-2398775-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE Cornell University (US) 2011-12-28 EP claimed
WO-2010096584-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE CORNELL UNIVERSITY (US) 2010-08-26 WO claimed
US-20250043290-A1 RNA SEQUENCES THAT INDUCE FLUORESCENCE OF SMALL MOLECULE FLUOROPHORES, MOLECULAR COMPLEXES, SENSORS, AND METHODS OF USE THEREOF CORNELL UNIVERSITY 2025-02-06 US disclosed
US-11453646-B2 Methods for RNA detection and quantification CORNELL UNIVERSITY (US) 2022-09-27 US disclosed
US-11174505-B2 Simple one-step real-time molecular system for microRNA detection AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2021-11-16 US disclosed
US-10444224-B2 Method for RNA detection and quantification CORNELL UNIVERSITY (US) 2019-10-15 US disclosed
US-20190185934-A1 METHODS FOR RNA DETECTION AND QUANTIFICATION UNIV CORNELL (US) 2019-06-20 US disclosed
US-10316000-B2 Coupled recognition/detection system for in vivo and in vitro use CORNELL UNIVERSITY (US) 2019-06-11 US disclosed
EP-2398775-B1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE UNIV CORNELL (US) 2019-04-24 EP disclosed
WO-2017146653-A1 A SIMPLE ONE-STEP REAL-TIME MOLECULAR SYSTEM FOR MICRORNA DETECTION AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2017-08-31 WO disclosed
EP-3211083-A1 FLUORESCENT APTAMERS AND THEIR APPLICATIONS Centre National De La Recherche Scientifique (FR) 2017-08-30 EP disclosed
US-9664676-B2 RNA sequences that induce fluorescence of small molecule fluorophores CORNELL UNIVERSITY (US) 2017-05-30 US disclosed
US-20150141282-A1 RNA SEQUENCES THAT INDUCE FLUORESCENCE OF SMALL MOLECULE FLUOROPHORES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-05-21 US disclosed
US-20140220560-A1 METHODS FOR RNA DETECTION AND QUANTIFICATION CORNELL UNIVERSITY (US) 2014-08-07 US disclosed
WO-2013016694-A2 METHODS FOR RNA DETECTION AND QUANTIFICATION CORNELL UNIVERSITY (US) 2013-01-31 WO disclosed
US-20120252699-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE CORNELL UNIVERSITY (US) 2012-10-04 US disclosed
EP-2398775-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE Cornell University (US) 2011-12-28 EP disclosed
WO-2010096584-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE CORNELL UNIVERSITY (US) 2010-08-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11453646-B2 Methods for RNA detection and quantification SNRPE, NSUN3, EFTUD2 KDR 2260/4885KMT2A 2486/4885L3MBTL1 290/4885
US-10316000-B2 Coupled recognition/detection system for in vivo and in vitro use DCLRE1B, TLR9, APEX1 KDR 1058/4885KMT2A 2945/4885L3MBTL1 778/4885
US-20120252699-A1 COUPLED RECOGNITION/DETECTION SYSTEM FOR IN VIVO AND IN VITRO USE DCLRE1B, TLR9, APEX1 KDR 1058/4885KMT2A 2945/4885L3MBTL1 778/4885
US-10444224-B2 Method for RNA detection and quantification SNRPE, NSUN3, EFTUD2 KDR 2280/4885KMT2A 2455/4885L3MBTL1 332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.