Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 4/20 | 0.31 |
| ▸ | CA1 | P00915 | 4/20 | 0.31 |
| ▸ | CA2 | P00918 | 4/20 | 0.31 |
| ▸ | CA9 | Q16790 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437495 | 0.97 | TSHR (0.60) | TSHRALDH1A1HSD17B10TDP1HCAR2 | |
| SCHEMBL288698 | 0.83 | TSHR (0.53) | TSHRALDH1A1HSD17B10HCAR2ADRA1A | |
| SCHEMBL3483417 | 0.81 | TSHR (0.52) | TSHRALDH1A1HSD17B10HCAR2ADRA1A | |
| SCHEMBL28905862 | 0.78 | TSHR (0.82) | TSHRALDH1A1HSD17B10TDP1HCAR2 | |
| SCHEMBL27840863 | 0.77 | — | — | |
| SCHEMBL22733779 | 0.77 | TSHR (0.43) | TSHRALDH1A1HSD17B10TDP1CHRM2 | |
| SCHEMBL6471616 | 0.77 | TSHR (0.48) | TSHRALDH1A1HSD17B10TDP1HCAR2 | |
| SCHEMBL36670 | 0.76 | TSHR (0.59) | TSHRALDH1A1HSD17B10HCAR2ADRA1A | |
| SCHEMBL27864875 | 0.76 | ALDH1A1 (0.64) | TSHRALDH1A1HSD17B10TDP1BLM | |
| SCHEMBL5490374 | 0.76 | TSHR (0.46) | TSHRALDH1A1HSD17B10HCAR2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396314-A1 | PROCESS FOR PREPARATION OF BEZOYL AMINO HETEROCYCLYL COMPOUNDS | AstraZeneca AB (SE) | 2011-12-21 | — | — | EP | disclosed |
| EP-2396317-A1 | CRYSTALLINE POLYMORPHIC FORM 631 | AstraZeneca AB (SE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092386-A1 | CRYSTALLINE POLYMORPHIC FORM 631 | ASTRAZENECA AB (SE) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010092387-A1 | PROCESS FOR PREPARATION OF BEZOYL AMINO HETEROCYCLYL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-08-19 | — | — | WO | disclosed |