Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165599 | 0.90 | — | — | |
| SCHEMBL8902693 | 0.88 | CYP2D6 (0.41) | GLRA1SLC6A9OR51E2ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL791648 | 0.87 | — | — | |
| Ammonia Solution, Strong SCHEMBL28014704 | 0.85 | — | — | |
| Glycine SCHEMBL27813806 | 0.78 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2CYP2D6ALDH1A1 | |
| Glycine SCHEMBL1148008 | 0.73 | — | — | |
| Glycine SCHEMBL29013695 | 0.73 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2ALOX15HSD17B10 | |
| Glycine SCHEMBL5985162 | 0.73 | GLRA1 (0.43) | GLRA1SLC6A9OR51E2CYP2D6ALDH1A1 | |
| SCHEMBL19672582 | 0.73 | ALDH1A1 (0.39) | ALOX15HSD17B10ALDH1A1MAPTBLM | |
| SCHEMBL13858299 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675905-A1 | TP53 AS BIOMARKER FOR RESPONSIVENESS TO IMMUNOTHERAPY | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-07-08 | — | — | EP | disclosed |
| WO-2019046619-A1 | TP53 AS BIOMARKER FOR RESPONSIVENESS TO IMMUNOTHERAPY | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2016011498-A1 | COMPOSITIONS AND METHODS OF USE | MELCARE MEDICAL PTY LTD (AU) | 2016-01-28 | — | — | WO | disclosed |
| WO-2010085290-A1 | METHODS FOR PREVENTION AND/OR TREATMENT OF CAPSULAR CONTRACTURE | J&E SOLUTIONS, LLC (US) | 2010-07-29 | — | — | WO | disclosed |