Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 18/20 | 0.78 |
| ▸ | ADORA2A | P29274 | 16/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20784311 | 1.00 | ADORA2B (0.78) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL20784691 | 0.90 | ADORA2B (0.74) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL20784690 | 0.90 | ADORA2B (0.74) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL20784309 | 0.89 | ADORA2B (0.81) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL24261160 | 0.89 | ADORA2B (0.81) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL24261250 | 0.88 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL20785020 | 0.88 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL24261255 | 0.88 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL20785019 | 0.88 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1 | |
| SCHEMBL20784339 | 0.88 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046784-A1 | COMPOUNDS AND METHODS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR | CORVUS PHARMACEUTICALS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| EP-2207780-B1 | THIENOPYRIMIDINE COMPOUNDS AND COMPOSITIONS | VERNALIS R&D LTD (GB) | 2013-05-15 | — | — | EP | disclosed |
| US-8354415-B2 | Thienopyrimidine compounds and compositions | VERNALIS (R&D) LTD. (GB) | 2013-01-15 | — | — | US | disclosed |
| EP-2207780-A1 | THIENOPYRIMIDINE COMPOUNDS AND COMPOSITIONS | Vernalis (R&D) Ltd. (GB) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009037468-A1 | THIENOPYRIMIDINE COMPOUNDS AND COMPOSITIONS | VERNALIS (R & D) LTD. (GB) | 2009-03-26 | — | — | WO | disclosed |