Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 10/20 | 0.83 |
| ▸ | HPGD | P15428 | 10/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.81 |
| ▸ | CASP1 | P29466 | 3/20 | 0.81 |
| ▸ | USP2 | O75604 | 2/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.76 |
| ▸ | MEN1 | O00255 | 6/20 | 0.76 |
| ▸ | TLR4 | O00206 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | CASP7 | P55210 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4216633 | 0.91 | TSHR (1.00) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4213854 | 0.90 | ALDH1A1 (1.00) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4205349 | 0.89 | KDM4E (0.83) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4205363 | 0.87 | ALDH1A1 (1.00) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4211561 | 0.84 | KMT2A (0.73) | TSHRHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4206201 | 0.83 | ALDH1A1 (1.00) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4204438 | 0.82 | ALDH1A1 (0.78) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4204303 | 0.81 | HPGD (0.82) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4209666 | 0.79 | KDM4E (0.84) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4203027 | 0.77 | KDM4E (0.75) | TSHRHPGDL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | disclosed |