Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL258720 | 0.85 | PDE10A (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL259105 | 0.80 | PDE10A (0.48) | RAB9ANPC1SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL259076 | 0.78 | PDE10A (0.52) | — | |
| Hydrochloric Acid SCHEMBL16972416 | 0.76 | PDE10A (0.51) | — | |
| SCHEMBL10984128 | 0.75 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL259679 | 0.71 | PDE10A (0.54) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4118545 | 0.70 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL31570811 | 0.69 | NPC1 (0.48) | RAB9ANPC1SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL259066 | 0.69 | PDE10A (0.55) | RAB9ANPC1MAPK1MAPTGAA | |
| SCHEMBL3629833 | 0.69 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |