Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978550 | 0.89 | GAA (0.42) | GAAMAPK1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL1395413 | 0.89 | MAPK1 (0.43) | GAAMAPK1SMN1; SMN2L3MBTL1BCL2 | |
| SCHEMBL10977335 | 0.87 | SMN1; SMN2 (0.51) | GAAMAPK1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL370827 | 0.87 | GAA (0.43) | GAAMAPK1SMN1; SMN2L3MBTL1BCL2 | |
| SCHEMBL13214510 | 0.84 | SLC6A3 (0.44) | GAAMAPK1SMN1; SMN2L3MBTL1BCL2 | |
| SCHEMBL1390375 | 0.83 | SMN1; SMN2 (0.42) | GAAMAPK1SMN1; SMN2L3MBTL1BCL2 | |
| SCHEMBL10363351 | 0.82 | GAA (0.45) | GAAMAPK1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL490341 | 0.82 | SMN1; SMN2 (0.53) | GAAMAPK1SMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL3013426 | 0.81 | S1PR3 (0.40) | GAAMAPK1SMN1; SMN2L3MBTL1BCL2 | |
| SCHEMBL363529 | 0.79 | S1PR3 (0.39) | GAAMAPK1SMN1; SMN2L3MBTL1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |