Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719145 | 0.84 | TRPV1 (0.47) | MAPK14CYP1A2CYP2C19BCHEMAPK10 | |
| SCHEMBL4592340 | 0.84 | KDM4E (0.41) | CACNA1BPDE3BPDE3ALIMK2DPP4 | |
| SCHEMBL4600287 | 0.83 | KCNA5 (0.43) | LIMK2DPP4CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL9030551 | 0.82 | TRPV1 (0.46) | MAPK14CYP1A2CYP2C19BCHEMAPK10 | |
| SCHEMBL3711456 | 0.82 | DPP4 (0.50) | MAPK14CYP1A2CYP2C19BCHEMAPK10 | |
| SCHEMBL17456048 | 0.81 | CYP11B1 (0.44) | MAPK14LIMK2DPP4CYP11B1CYP11B2 | |
| SCHEMBL3907145 | 0.79 | MAOB (0.44) | MAPK14CYP1A2CYP2C19BCHEMAPK10 | |
| SCHEMBL11256542 | 0.79 | BCHE (0.47) | MAPK14BCHEMAPK10PDE3BPDE3A | |
| SCHEMBL3906663 | 0.78 | MAPK14 (0.40) | MAPK14CYP1A2CYP2C19BCHEMAPK10 | |
| SCHEMBL8938109 | 0.78 | MAPK14 (0.40) | MAPK14CYP1A2CYP2C19BCHEMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | claimed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |