Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188684 | 0.93 | PIK3CG (0.36) | ABL1PIK3CGPIK3CADYRK1APIK3CD | |
| SCHEMBL13188683 | 0.93 | PIK3CG (0.36) | ABL1PIK3CGPIK3CADYRK1APIK3CD | |
| SCHEMBL3711298 | 0.90 | DYRK1A (0.43) | ABL1PIK3CGPIK3CADYRK1APIK3CD | |
| SCHEMBL13188928 | 0.88 | DYRK1A (0.40) | ABL1PIK3CGPIK3CADYRK1APIK3CD | |
| SCHEMBL13188288 | 0.87 | PIK3CG (0.50) | ABL1PIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL13189027 | 0.87 | PIK3CG (0.50) | ABL1PIK3CGPIK3CADYRK1A | |
| SCHEMBL13188931 | 0.87 | PIK3CG (0.38) | ABL1PIK3CGPIK3CADYRK1APIK3CD | |
| SCHEMBL13188177 | 0.86 | ABL1 (0.41) | ABL1PIK3CGPIK3CADYRK1A | |
| SCHEMBL13188581 | 0.85 | PIK3CG (0.44) | ABL1PIK3CGPIK3CA | |
| SCHEMBL13188532 | 0.83 | DYRK1A (0.41) | ABL1PIK3CGPIK3CADYRK1APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |