Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188532 | 0.93 | DYRK1A (0.41) | DYRK1AABL1NPC1RAB9AKDM4E | |
| SCHEMBL13188554 | 0.93 | DYRK1A (0.41) | DYRK1AABL1NPC1RAB9AKDM4E | |
| SCHEMBL3708403 | 0.90 | ABL1 (0.37) | DYRK1AABL1NPC1RAB9AKDM4E | |
| SCHEMBL13188304 | 0.87 | ABL1 (0.49) | ABL1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13188541 | 0.86 | NPC1 (0.42) | ABL1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13188177 | 0.85 | ABL1 (0.41) | DYRK1AABL1PIK3CAPIK3CG | |
| SCHEMBL13188684 | 0.83 | PIK3CG (0.36) | DYRK1AABL1NPC1RAB9AKDM4E | |
| SCHEMBL13188683 | 0.83 | PIK3CG (0.36) | DYRK1AABL1NPC1RAB9AKDM4E | |
| SCHEMBL13188390 | 0.81 | ABL1 (0.47) | ABL1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13188928 | 0.80 | DYRK1A (0.40) | DYRK1AABL1NPC1RAB9APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |